Virucidal or Not Virucidal? That Is the Question-Predictability of Ionic Liquid's Virucidal Potential in Biological Test Systems.
Identifieur interne : 000C05 ( Main/Exploration ); précédent : 000C04; suivant : 000C06Virucidal or Not Virucidal? That Is the Question-Predictability of Ionic Liquid's Virucidal Potential in Biological Test Systems.
Auteurs : Julia Sommer [Autriche] ; Susanne Fister [Autriche] ; Tobias Gundolf [Autriche] ; Birgit Bromberger [Autriche] ; Patrick-Julian Mester [Autriche] ; Anna Kristina Witte [Autriche] ; Roland Kalb [Autriche] ; Peter Rossmanith [Autriche]Source :
- International journal of molecular sciences [ 1422-0067 ] ; 2018.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- Antiviral Agents (chemistry), Antiviral Agents (pharmacology), DNA Viruses (drug effects), Escherichia coli (drug effects), Humans, Ionic Liquids (chemistry), Ionic Liquids (pharmacology), Listeria monocytogenes (drug effects), Pseudomonas syringae (drug effects), RNA Viruses (drug effects), Structure-Activity Relationship, Taq Polymerase (drug effects).
- MESH :
- chemical , chemistry : Antiviral Agents, Ionic Liquids.
- chemical , drug effects : Taq Polymerase.
- chemical , pharmacology : Antiviral Agents, Ionic Liquids.
- drug effects : DNA Viruses, Escherichia coli, Listeria monocytogenes, Pseudomonas syringae, RNA Viruses.
- Humans, Structure-Activity Relationship.
Abstract
For three decades now, ionic liquids (ILs), organic salts comprising only ions, have emerged as a new class of pharmaceuticals. Although recognition of the antimicrobial effects of ILs is growing rapidly, there is almost nothing known about their possible virucidal activities. This probably reflects the paucity of understanding virus inactivation. In this study, we performed a systematic analysis to determine the effect of specific structural motifs of ILs on three different biological test systems (viruses, bacteria and enzymes). Overall, the effects of 27 different ILs on two non-enveloped and one enveloped virus (P100, MS2 and Phi6), two Gram negative and one Gram positive bacteria (E. coli, P. syringae and L. monocytogenes) and one enzyme (Taq DNA polymerase) were investigated. Results show that while some ILs were virucidal, no clear structure activity relationships (SARs) could be identified for the non-enveloped viruses P100 and MS2. However, for the first time, a correlation has been demonstrated between the effects of ILs on enveloped viruses, bacteria and enzyme inhibition. These identified SARs serve as a sound starting point for further studies.
DOI: 10.3390/ijms19030790
PubMed: 29522483
Affiliations:
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Anna.witte@vetmeduni.ac.at.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Christian Doppler-Laboratory for Monitoring of Microbial Contaminants, Institute of Milk Hygiene, Milk Technology and Food Science, Department for Farm Animal and Public Veterinary Health, University of Veterinary Medicine, Veterinärplatz 1, 1210 Vienna</wicri:regionArea><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement></placeName></affiliation></author><author><name sortKey="Kalb, Roland" sort="Kalb, Roland" uniqKey="Kalb R" first="Roland" last="Kalb">Roland Kalb</name><affiliation wicri:level="1"><nlm:affiliation>Proionic Production of Ionic Substances GmbH, 8074 Grambach, Austria. roland.kalb@proionic.com.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Proionic Production of Ionic Substances GmbH, 8074 Grambach</wicri:regionArea><wicri:noRegion>8074 Grambach</wicri:noRegion></affiliation></author><author><name sortKey="Rossmanith, Peter" sort="Rossmanith, Peter" uniqKey="Rossmanith P" first="Peter" last="Rossmanith">Peter Rossmanith</name><affiliation wicri:level="3"><nlm:affiliation>Christian Doppler-Laboratory for Monitoring of Microbial Contaminants, Institute of Milk Hygiene, Milk Technology and Food Science, Department for Farm Animal and Public Veterinary Health, University of Veterinary Medicine, Veterinärplatz 1, 1210 Vienna, Austria. 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That Is the Question-Predictability of Ionic Liquid's Virucidal Potential in Biological Test Systems.</title><author><name sortKey="Sommer, Julia" sort="Sommer, Julia" uniqKey="Sommer J" first="Julia" last="Sommer">Julia Sommer</name><affiliation wicri:level="3"><nlm:affiliation>Christian Doppler-Laboratory for Monitoring of Microbial Contaminants, Institute of Milk Hygiene, Milk Technology and Food Science, Department for Farm Animal and Public Veterinary Health, University of Veterinary Medicine, Veterinärplatz 1, 1210 Vienna, Austria. Julia.sommer@vetmeduni.ac.at.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Christian Doppler-Laboratory for Monitoring of Microbial Contaminants, Institute of Milk Hygiene, Milk Technology and Food Science, Department for Farm Animal and Public Veterinary Health, University of Veterinary Medicine, Veterinärplatz 1, 1210 Vienna</wicri:regionArea><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement></placeName></affiliation></author><author><name sortKey="Fister, Susanne" sort="Fister, Susanne" uniqKey="Fister S" first="Susanne" last="Fister">Susanne Fister</name><affiliation wicri:level="3"><nlm:affiliation>Christian Doppler-Laboratory for Monitoring of Microbial Contaminants, Institute of Milk Hygiene, Milk Technology and Food Science, Department for Farm Animal and Public Veterinary Health, University of Veterinary Medicine, Veterinärplatz 1, 1210 Vienna, Austria. Susanne.fister@vetmeduni.ac.at.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Christian Doppler-Laboratory for Monitoring of Microbial Contaminants, Institute of Milk Hygiene, Milk Technology and Food Science, Department for Farm Animal and Public Veterinary Health, University of Veterinary Medicine, Veterinärplatz 1, 1210 Vienna</wicri:regionArea><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement></placeName></affiliation></author><author><name sortKey="Gundolf, Tobias" sort="Gundolf, Tobias" uniqKey="Gundolf T" first="Tobias" last="Gundolf">Tobias Gundolf</name><affiliation wicri:level="3"><nlm:affiliation>Christian Doppler-Laboratory for Monitoring of Microbial Contaminants, Institute of Milk Hygiene, Milk Technology and Food Science, Department for Farm Animal and Public Veterinary Health, University of Veterinary Medicine, Veterinärplatz 1, 1210 Vienna, Austria. Tobias.gundolf@vetmeduni.ac.at.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Christian Doppler-Laboratory for Monitoring of Microbial Contaminants, Institute of Milk Hygiene, Milk Technology and Food Science, Department for Farm Animal and Public Veterinary Health, University of Veterinary Medicine, Veterinärplatz 1, 1210 Vienna</wicri:regionArea><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement></placeName></affiliation></author><author><name sortKey="Bromberger, Birgit" sort="Bromberger, Birgit" uniqKey="Bromberger B" first="Birgit" last="Bromberger">Birgit Bromberger</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Milk Hygiene, Milk Technology and Food Science, Department for Farm Animal and Public Veterinary Health, University of Veterinary Medicine, Veterinärplatz 1, 1210 Vienna, Austria. Birgit.bromberger@vetmeduni.ac.at.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute of Milk Hygiene, Milk Technology and Food Science, Department for Farm Animal and Public Veterinary Health, University of Veterinary Medicine, Veterinärplatz 1, 1210 Vienna</wicri:regionArea><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement></placeName></affiliation></author><author><name sortKey="Mester, Patrick Julian" sort="Mester, Patrick Julian" uniqKey="Mester P" first="Patrick-Julian" last="Mester">Patrick-Julian Mester</name><affiliation wicri:level="3"><nlm:affiliation>Christian Doppler-Laboratory for Monitoring of Microbial Contaminants, Institute of Milk Hygiene, Milk Technology and Food Science, Department for Farm Animal and Public Veterinary Health, University of Veterinary Medicine, Veterinärplatz 1, 1210 Vienna, Austria. Patrick-julian.mester@vetmeduni.ac.at.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Christian Doppler-Laboratory for Monitoring of Microbial Contaminants, Institute of Milk Hygiene, Milk Technology and Food Science, Department for Farm Animal and Public Veterinary Health, University of Veterinary Medicine, Veterinärplatz 1, 1210 Vienna</wicri:regionArea><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement></placeName></affiliation></author><author><name sortKey="Witte, Anna Kristina" sort="Witte, Anna Kristina" uniqKey="Witte A" first="Anna Kristina" last="Witte">Anna Kristina Witte</name><affiliation wicri:level="3"><nlm:affiliation>Christian Doppler-Laboratory for Monitoring of Microbial Contaminants, Institute of Milk Hygiene, Milk Technology and Food Science, Department for Farm Animal and Public Veterinary Health, University of Veterinary Medicine, Veterinärplatz 1, 1210 Vienna, Austria. Anna.witte@vetmeduni.ac.at.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Christian Doppler-Laboratory for Monitoring of Microbial Contaminants, Institute of Milk Hygiene, Milk Technology and Food Science, Department for Farm Animal and Public Veterinary Health, University of Veterinary Medicine, Veterinärplatz 1, 1210 Vienna</wicri:regionArea><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement></placeName></affiliation></author><author><name sortKey="Kalb, Roland" sort="Kalb, Roland" uniqKey="Kalb R" first="Roland" last="Kalb">Roland Kalb</name><affiliation wicri:level="1"><nlm:affiliation>Proionic Production of Ionic Substances GmbH, 8074 Grambach, Austria. roland.kalb@proionic.com.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Proionic Production of Ionic Substances GmbH, 8074 Grambach</wicri:regionArea><wicri:noRegion>8074 Grambach</wicri:noRegion></affiliation></author><author><name sortKey="Rossmanith, Peter" sort="Rossmanith, Peter" uniqKey="Rossmanith P" first="Peter" last="Rossmanith">Peter Rossmanith</name><affiliation wicri:level="3"><nlm:affiliation>Christian Doppler-Laboratory for Monitoring of Microbial Contaminants, Institute of Milk Hygiene, Milk Technology and Food Science, Department for Farm Animal and Public Veterinary Health, University of Veterinary Medicine, Veterinärplatz 1, 1210 Vienna, Austria. Peter.rossmanith@vetmeduni.ac.at.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Christian Doppler-Laboratory for Monitoring of Microbial Contaminants, Institute of Milk Hygiene, Milk Technology and Food Science, Department for Farm Animal and Public Veterinary Health, University of Veterinary Medicine, Veterinärplatz 1, 1210 Vienna</wicri:regionArea><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement></placeName></affiliation></author></analytic><series><title level="j">International journal of molecular sciences</title><idno type="eISSN">1422-0067</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral Agents (chemistry)</term><term>Antiviral Agents (pharmacology)</term><term>DNA Viruses (drug effects)</term><term>Escherichia coli (drug effects)</term><term>Humans</term><term>Ionic Liquids (chemistry)</term><term>Ionic Liquids (pharmacology)</term><term>Listeria monocytogenes (drug effects)</term><term>Pseudomonas syringae (drug effects)</term><term>RNA Viruses (drug effects)</term><term>Structure-Activity Relationship</term><term>Taq Polymerase (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antiviraux ()</term><term>Antiviraux (pharmacologie)</term><term>Escherichia coli ()</term><term>Humains</term><term>Liquides ioniques ()</term><term>Liquides ioniques (pharmacologie)</term><term>Listeria monocytogenes ()</term><term>Pseudomonas syringae ()</term><term>Relation structure-activité</term><term>TAQ polymerase ()</term><term>Virus à ADN ()</term><term>Virus à ARN ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antiviral Agents</term><term>Ionic Liquids</term></keywords><keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Taq Polymerase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Ionic Liquids</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>DNA Viruses</term><term>Escherichia coli</term><term>Listeria monocytogenes</term><term>Pseudomonas syringae</term><term>RNA Viruses</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Liquides ioniques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Structure-Activity Relationship</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Antiviraux</term><term>Escherichia coli</term><term>Humains</term><term>Liquides ioniques</term><term>Listeria monocytogenes</term><term>Pseudomonas syringae</term><term>Relation structure-activité</term><term>TAQ polymerase</term><term>Virus à ADN</term><term>Virus à ARN</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">For three decades now, ionic liquids (ILs), organic salts comprising only ions, have emerged as a new class of pharmaceuticals. Although recognition of the antimicrobial effects of ILs is growing rapidly, there is almost nothing known about their possible virucidal activities. This probably reflects the paucity of understanding virus inactivation. In this study, we performed a systematic analysis to determine the effect of specific structural motifs of ILs on three different biological test systems (viruses, bacteria and enzymes). Overall, the effects of 27 different ILs on two non-enveloped and one enveloped virus (P100, MS2 and Phi6), two Gram negative and one Gram positive bacteria (<i>E. coli</i>, <i>P. syringae</i> and <i>L. monocytogenes</i>) and one enzyme (Taq DNA polymerase) were investigated. Results show that while some ILs were virucidal, no clear structure activity relationships (SARs) could be identified for the non-enveloped viruses P100 and MS2. However, for the first time, a correlation has been demonstrated between the effects of ILs on enveloped viruses, bacteria and enzyme inhibition. These identified SARs serve as a sound starting point for further studies.</div></front></TEI><affiliations><list><country><li>Autriche</li></country><region><li>Vienne (Autriche)</li></region><settlement><li>Vienne (Autriche)</li></settlement></list><tree><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Sommer, Julia" sort="Sommer, Julia" uniqKey="Sommer J" first="Julia" last="Sommer">Julia Sommer</name></region><name sortKey="Bromberger, Birgit" sort="Bromberger, Birgit" uniqKey="Bromberger B" first="Birgit" last="Bromberger">Birgit Bromberger</name><name sortKey="Fister, Susanne" sort="Fister, Susanne" uniqKey="Fister S" first="Susanne" last="Fister">Susanne Fister</name><name sortKey="Gundolf, Tobias" sort="Gundolf, Tobias" uniqKey="Gundolf T" first="Tobias" last="Gundolf">Tobias Gundolf</name><name sortKey="Kalb, Roland" sort="Kalb, Roland" uniqKey="Kalb R" first="Roland" last="Kalb">Roland Kalb</name><name sortKey="Mester, Patrick Julian" sort="Mester, Patrick Julian" uniqKey="Mester P" first="Patrick-Julian" last="Mester">Patrick-Julian Mester</name><name sortKey="Rossmanith, Peter" sort="Rossmanith, Peter" uniqKey="Rossmanith P" first="Peter" last="Rossmanith">Peter Rossmanith</name><name sortKey="Witte, Anna Kristina" sort="Witte, Anna Kristina" uniqKey="Witte A" first="Anna Kristina" last="Witte">Anna Kristina Witte</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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